Maine Health

Technical Bulletins

25 bulletins:

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Word   Lyme Immunoblot Technical Bulletin 2015-MII
Lyme Immunoblot Technical Bulletin 2015-MII
Word   TREP Reverse Sequence Algorithm
TREP-SURE Syphilis Screening Algorithm
Word   TREPONEMA PALLIDUM AB (Syphilis) IgG and IgM, Serum
Effective June 30, 2015, NorDx will start offering the new algorithm for reverse sequence syphilis screening based on the 2009 Laboratory Guidelines proposed by the Association of Public Health Laboratories Expert Consultation Meeting Summary Report, of 2009 in Atlanta, GA in association with the CDC.
Word   Sysmex XN News Release
NorDx, (Northern Diagnostic Laboratories), the largest reference laboratory in the state of Maine and a member of MaineHealth, today announces the acquisition of Sysmex® XN-Series Automated Hematology Analyzers.
Word   Clostridium difficile Toxin Gene Detection by DNA amplification
Because of their low sensitivity, enzyme immunoassay (EIA) tests are no longer recommended for detection of C. difficile toxin in stool specimens. Recent reports indicate that molecular assays like the polymerase chain reaction (PCR) provide sensitivities and specificities comparable to toxigenic culture, the current "gold standard", and provide significantly shorter turnaround times.
Word   Hepatitis B Viral DNA, Quantitative
Effective April 2011, NorDx will begin using version 2.0 of the IVD HBV real-time PCR test for quantitative HBV viral load testing. The expanded quantitative range of the assay is 20 to 170,000,000 IU/ml.
Word   BCR/ABL Quant p210
The Philadelphia chromosome results from a translocation on [t (9;22)(q34;q11.2)] that fuses the ABL proto-oncogene on chromosome 9 to the BCR (breakpoint cluster region) gene on chromosome 22. In chronic myelogenous leukemia (CML), the great majority of breakpoints occur within the 5.8 Kb major breakpoint cluster region (M-BCR). The BCR-ABL transcript is translated into a 210kD fusion protein (p210). This BCR-ABL fusion transcript is quantified relative to the normal ABL transcripts using real time RT- PCR.
Word   Influenza A/B screening w/reflex to Influenza A sub-typing
The Flu A/B RT-PCR screen test detects and differentiates between Influenza A and B viruses. If Influenza A virus is detected, the test will reflex to Influenza A subtyping to differentiate between the novel 2009 H1N1 and seasonal Influenza A viruses (H1 and H3). Molecular-based assays demonstrate higher sensitivity and specificity than other screening methods.
Word   Human Papilloma virus, Genotyping
HPV genotyping will be performed using the Cervista HPV 16/18 IVD test. HPV genotyping can be ordered on patients that have tested positive for the HPV high risk screen (HPVHR, HPVH, or HPVHO).
Word   Lipid Profile LDL-D Reflex Testing
The Centers for Medicare and Medicaid Services (CMS) has issued through their National Coverage Determinations (NCDs) guidelines pertaining to lipid testing. They state that: The serum LDL cholesterol concentration may be calculated using the Friedenwald formula (LDL=total cholesterol - HDL -triglycerides/5). However, if the triglyceride level is greater than 400 mg/dL, the LDL should be measured directly. Further, the calculation may not accurately determine the LDL level in alcoholic patients. These patients may also require direct measurement of the serum LDL.

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